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Poor/In depth Metabolizers, CYP2D6 The formation on the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around seven% in the inhabitants has lessened exercise in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These folks are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressa